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Bowel cancer screening · For UK healthcare providers
ColoAlert® bowel cancer screening test
A home stool test that combines immunochemical testing with DNA analysis in a single sample. Biox Medical supplies ColoAlert to UK pharmacies, private clinics and laboratories.
Why two methods
Blood and DNA markers in one sample
Most home bowel tests look only for hidden blood in the stool. Some bowel cancers and pre-cancerous growths don't bleed all the time, so a blood-only test can miss them on the day the sample is taken.
ColoAlert combines a quantitative immunochemical test for blood with DNA analysis. It measures the amount of human DNA in the sample and looks for 27 variants of the KRAS and BRAF genes. All of this comes from one sample, collected at home.
Healthcare partners can ask for our partner brochure, which includes the clinical evidence and a comparison with qFIT and Cologuard, and a copy of the full study.
At a glance
- What it tests
- Quantitative immunochemical test (haemoglobin and haptoglobin), human DNA quantification, and 27 KRAS and BRAF variants (qPCR)
- Sample
- One stool sample, collected at home
- Who it's for
- Adults aged 45+ without bowel symptoms
- Manufacturer
- biovis Diagnostik MVZ GmbH, Germany (Test Set 920)
- Laboratory
- biovis, Limburg-Eschhofen, accredited to DIN EN ISO 15189
- Sample return
- UN3373-compliant packaging included with every kit
- Results
- Usually around 10 days, sent by password-encrypted email
- Abnormal results
- Reviewed and discussed free of charge by a GP
Clinical performance
What the study found
In the most recent peer-reviewed study of ColoAlert:
- 84.2%
- of colorectal cancers detected, across all stages (sensitivity)
- 91.5%
- of people without cancer correctly given a negative result (specificity)
- 75%
- of high-grade dysplasia detected, a pre-cancerous change
Source: Krammes et al., Clinical Laboratory 2025;71:34–39. No screening test detects every cancer, so a negative result does not rule out bowel cancer.
“I didn’t want to know… but I think it’s so important.”
The process
How a ColoAlert test works
Kit supplied
Through a partner pharmacy or clinic, or bought directly from MeCheck.
Sample at home
The patient collects one small stool sample in private, following the step-by-step instructions.
Posted to the lab
The sample goes back in the UN3373-compliant packaging supplied, for analysis at biovis in Germany.
Results reported
Partner clinics report results to their own patients. MeCheck orders are reported by Northwest Health Ltd, a CQC-registered clinic.
Understanding results
What a result means
Normal result
No markers were found above the threshold. A normal result does not rule out bowel cancer. Anyone who develops symptoms should see their GP, whatever the test said.
Abnormal result
This is not a diagnosis. It means further investigation is needed, usually a colonoscopy. A GP reviews and discusses every abnormal result free of charge and advises on next steps.
Important: screening tests are for people without symptoms. They are not a diagnosis and do not replace assessment by a doctor. If you have bleeding, a persistent change in bowel habit, unexplained weight loss, abdominal pain or unexplained tiredness, contact your GP without delay.
Questions
ColoAlert FAQ
What is the regulatory status of ColoAlert?
Test Set 920 (ColoAlert) is manufactured by biovis Diagnostik MVZ GmbH as an in-house medical device under Regulations (EU) 2017/745 and 2017/746. The stool collection tube is CE-IVD marked. Samples are analysed exclusively at biovis in Limburg-Eschhofen, Germany, a laboratory accredited to DIN EN ISO 15189.
Who should not use ColoAlert?
People with bowel symptoms should see their GP rather than use a home screening test. The test is intended for adults aged 45 and over without symptoms.
Who reports results to patients?
Tests supplied through a partner clinic are reported by that clinic. Tests bought through MeCheck are reported by Northwest Health Ltd, a CQC-registered clinic.
How do I start offering ColoAlert?
Send us an enquiry. The minimum order is ten kits, and partner pricing is available on request. Once we have your delivery address, a named clinical contact, an accounts email and your opening quantity, we can dispatch within 48 hours.
For pharmacies, clinics & labs
Offer ColoAlert to your patients
We supply kits, return packaging and laboratory reporting, so you can add advanced bowel screening without building it yourself.
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